FGFR2 R478K
Gene Variant Detail

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Gene FGFR2
Variant R478K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 R478K lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). R478K does not significantly alter serum dependency for growth in cell culture (PMID: 40526877), but has not been fully biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 R478K

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Transcript NM_000141.5
gDNA chr10:g.121503796C>T
cDNA c.1433G>A
Protein p.R478K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121503796C>T c.1433G>A p.R478K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References