FGFR2 V12M
Gene Variant Detail

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Gene FGFR2
Variant V12M
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 V12M does not lie within any known functional domains of the Fgfr2 protein (UniProt.org). V12M results in increased serum dependency for growth in culture (PMID: 40526877), and therefore, is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 inact mut FGFR2 V12M

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Transcript NM_000141.5
gDNA chr10:g.121593784C>T
cDNA c.34G>A
Protein p.V12M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144914.1 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_001144915.2 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121593784C>T c.34G>A p.V12M RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References