FGFR2 R425W
Gene Variant Detail

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Gene FGFR2
Variant R425W
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 R425W lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). R425W results in increased serum dependency for growth in culture (PMID: 40526877), and therefore, is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 inact mut FGFR2 R425W

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Transcript NM_000141.5
gDNA chr10:g.121515131G>A
cDNA c.1273C>T
Protein p.R425W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.2 chr10:g.121515131G>A c.1273C>T p.R425W RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515131G>A c.1273C>T p.R425W RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References