FGFR3 S424F
Gene Variant Detail

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Gene FGFR3
Variant S424F
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR3 S424F lies within the cytoplasmic domain of the Fgfr3 protein (UniProt.org). S424F results in decreased serum dependency for growth in culture (PMID: 40526877), and therefore, is predicted to lead to a gain of Fgfr3 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 act mut FGFR3 S424F

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Transcript NM_000142.5
gDNA chr4:g.1804828C>T
cDNA c.1271C>T
Protein p.S424F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000142.5 chr4:g.1804828C>T c.1271C>T p.S424F RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1804828C>T c.1271C>T p.S424F RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1804828C>T c.1271C>T p.S424F RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1804828C>T c.1271C>T p.S424F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 S424F Advanced Solid Tumor sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, Balversa (erdafitinib) inhibited viability of cells expressing FGFR3 S424F in culture (PMID: 40526877). 40526877
FGFR3 S424F Advanced Solid Tumor sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, Lytgobi (futibatinib) inhibited viability of cells expressing FGFR3 S424F in culture (PMID: 40526877). 40526877
FGFR3 S424F Advanced Solid Tumor sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, Pemazyre (pemigatinib) inhibited viability of cells expressing FGFR3 S424F in culture (PMID: 40526877). 40526877