FGFR3 A441T
Gene Variant Detail

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Gene FGFR3
Variant A441T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 A441T lies within the cytoplasmic domain of the Fgfr3 protein (UniProt.org). A441T does not significantly alter serum dependency for growth in cell culture (PMID: 40526877), but has not been fully biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 A441T

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Transcript NM_000142.5
gDNA chr4:g.1804878G>A
cDNA c.1321G>A
Protein p.A441T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713873.2 chr4:g.1804878G>A c.1321G>A p.A441T RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1804878G>A c.1321G>A p.A441T RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1804878G>A c.1321G>A p.A441T RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1804878G>A c.1321G>A p.A441T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References