FGFR3 R416C
Gene Variant Detail

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Gene FGFR3
Variant R416C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 R416C lies within the cytoplasmic domain of the Fgfr3 protein (UniProt.org). R416C does not significantly alter serum dependency for growth in cell culture (PMID: 40526877), but has not been fully biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 R416C

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Transcript NM_000142.5
gDNA chr4:g.1804500C>T
cDNA c.1246C>T
Protein p.R416C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011513420.2 chr4:g.1804500C>T c.1246C>T p.R416C RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.1804500C>T c.1246C>T p.R416C RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1804500C>T c.1246C>T p.R416C RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1804500C>T c.1246C>T p.R416C RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1804500C>T c.1246C>T p.R416C RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1804500C>T c.1246C>T p.R416C RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.1804500C>T c.1246C>T p.R416C RefSeq GRCh38/hg38
NM_001354810.2 chr4:g.1804500C>T c.1246C>T p.R416C RefSeq GRCh38/hg38
XM_047449822.1 chr4:g.1804500C>T c.1246C>T p.R416C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References