FGFR3 P449S
Gene Variant Detail

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Gene FGFR3
Variant P449S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 P449S lies within the cytoplasmic domain of the Fgfr3 protein (UniProt.org). P449S does not significantly alter serum dependency for growth in cell culture (PMID: 40526877), but has not been fully biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 P449S

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Transcript NM_000142.5
gDNA chr4:g.1804902C>T
cDNA c.1345C>T
Protein p.P449S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713873.2 chr4:g.1804902C>T c.1345C>T p.P449S RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1804902C>T c.1345C>T p.P449S RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1804902C>T c.1345C>T p.P449S RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1804902C>T c.1345C>T p.P449S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References