FLT3 V491L
Gene Variant Detail

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Gene FLT3
Variant V491L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 V491L lies within the extracellular domain of the Flt3 protein (UniProt.org). V491L has been identified in the scientific literature (PMID: 41487332, PMID: 37680325, PMID: 38502195), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2026).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 V491L

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Transcript NM_004119.3
gDNA chr13:g.28035621C>G
cDNA c.1471G>C
Protein p.V491L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28035621C>G c.1471G>C p.V491L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 V491L acute myeloid leukemia sensitive Gilteritinib Case Reports/Case Series Actionable In a clinical case study, Xospata (gilteritinib) treatment resulted in disappearance of peripheral blasts in a patient with acute myeloid leukemia harboring FLT3 V491L, and in a preclinical study, inhibited viability of patient-derived acute myeloid leukemia cells in culture (PMID: 41487332). 41487332