TP53 N288fs
Gene Variant Detail

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Gene TP53
Variant N288fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 N288fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 288 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). N288fs has not been biochemically characterized however, due to the effects of other truncation mutations downstream of N288 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 N288fs

TP53 mutant TP53 inact mut TP53 N288fs

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Transcript NM_000546.6
gDNA chr17:g.(7673758_7673759)
cDNA c.(862_861)
Protein p.N288fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.(7673758_7673759) c.(862_861) p.N288fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7673758_7673759) c.(862_861) p.N288fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7673758_7673759) c.(862_861) p.N288fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7673758_7673759) c.(862_861) p.N288fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7673758_7673759) c.(862_861) p.N288fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7673758_7673759) c.(862_861) p.N288fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7673758_7673759) c.(862_861) p.N288fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7673758_7673759) c.(862_861) p.N288fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7673758_7673759) c.(862_861) p.N288fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TP53 N288fs loss of function - predicted
TP53 Y220C TP53 N288fs