TP53 M66fs
Gene Variant Detail

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Gene TP53
Variant M66fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 M66fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 66 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). M66fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of M66 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon4 TP53 M66fs

TP53 mutant TP53 inact mut TP53 M66fs

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Transcript NM_000546.6
gDNA chr17:g.(7676173_7676174)
cDNA c.(196_195)
Protein p.M66fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.6 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7676173_7676174) c.(196_195) p.M66fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TP53 M66fs loss of function - predicted p53 Activator p53 Gene Therapy