APC V2194fs
Gene Variant Detail

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Gene APC
Variant V2194fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions APC V2194fs results in a change in the amino acid sequence of the Apc protein beginning at aa 2194 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). V2194fs has been identified in the scientific literature (PMID: 32923851, PMID: 33969073), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Apr 2026).
Associated Drug Resistance
Category Variants Paths

APC mutant APC V2194fs

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Transcript NM_000038.6
gDNA chr5:g.(112842173_112842174)
cDNA c.(6580_6579)
Protein p.V2194fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407450.1 chr5:g.(112842173_112842174) c.(6580_6579) p.V2194fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112842173_112842174) c.(6580_6579) p.V2194fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112842173_112842174) c.(6580_6579) p.V2194fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112842173_112842174) c.(6580_6579) p.V2194fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References