RAD51C E92D
Gene Variant Detail

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Gene RAD51C
Variant E92D
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions RAD51C E92D lies within a region of the Rad51c protein required for Holliday junction resolution activity and the RAD51B, RAD51D, and XRCC3-interacting region (UniProt.org). E92D maintains functional homology-directed DNA repair activity in cell culture reporter assays, and demonstrates binding to Rad51d and Xrcc3 similar to wild-type Rad51c in a yeast assay (PMID: 42625895), and therefore, is predicted to have no effect on Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C E92D

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Transcript NM_058216.3
gDNA chr17:g.58695061G>C
cDNA c.276G>C
Protein p.E92D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047436505.1 chr17:g.58695061G>C c.276G>C p.E92D RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695061G>C c.276G>C p.E92D RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695061G>C c.276G>C p.E92D RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695061G>C c.276G>C p.E92D RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695061G>C c.276G>C p.E92D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RAD51C E92D no effect - predicted