RAD51C R24L
Gene Variant Detail

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Gene RAD51C
Variant R24L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C R24L lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). R24L maintains functional homology-directed DNA repair activity in cell culture (PMID: 37253112), and retains the ability to complement hypersensitivity to mitomycin C and etoposide in RAD51C-deficient cells, but demonstrates impaired ability to rescue survival of RAD51C-deficient cells upon PARP inhibitor treatment in culture (PMID: 36562461), and results in decreased survival in a high-throughput cell culture assay (PMID: 39299233), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C R24L

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Transcript NM_058216.3
gDNA chr17:g.58692714G>T
cDNA c.71G>T
Protein p.R24L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.3 chr17:g.58692714G>T c.71G>T p.R24L RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58692714G>T c.71G>T p.R24L RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58692714G>T c.71G>T p.R24L RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58692714G>T c.71G>T p.R24L RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58692714G>T c.71G>T p.R24L RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References