RAD51C K84N
Gene Variant Detail

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Gene RAD51C
Variant K84N
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions RAD51C K84N lies within a region of the Rad51c protein required for Holliday junction resolution activity and the RAD51B, RAD51D, and XRCC3-interacting region of the Rad51c protein (UniProt.org). K84N retains binding to Rad51d similar to wild-type Rad51c in a yeast assay (PMID: 40670332), and demonstrates functional homology-directed DNA repair activity in culture (PMID: 40670332, PMID: 37253112), and therefore is predicted to have no effect on Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C K84N

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Transcript NM_058216.3
gDNA chr17:g.58695037G>C
cDNA c.252G>C
Protein p.K84N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002.5 chr17:g.58695037G>C c.252G>C p.K84N RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695037G>C c.252G>C p.K84N RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695037G>C c.252G>C p.K84N RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695037G>C c.252G>C p.K84N RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695037G>C c.252G>C p.K84N RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References