RAD51C D318N
Gene Variant Detail

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Gene RAD51C
Variant D318N
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51C D318N does not lie within any known functional domains of the Rad51c protein (UniProt.org). D318N retains binding to Rad51d similar to wild-type Rad51c in a yeast assay, but demonstrates defective homology-directed DNA repair activity in cell culture (PMID: 40670332), and therefore, is predicted to lead to a loss of Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C D318N

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Transcript NM_058216.3
gDNA chr17:g.58724087G>A
cDNA c.952G>A
Protein p.D318N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.3 chr17:g.58724087G>A c.952G>A p.D318N RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58724087G>A c.952G>A p.D318N RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries