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FBXW7 G423* - Gene Variant Detail

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Gene FBXW7
Variant G423*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions FBXW7 G423* results in a premature truncation of the Fbxw7 protein at amino acid 423 of 707 within the WD repeat domain (UniProt.org). G423* has not been characterized however, due to the effects of other truncation mutations downstream of G423 (PMID: 24838835), is predicted to lead to a loss of Fbxw7 protein function.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 inact mut FBXW7 G423*

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Transcript NM_033632.3
gDNA chr4:g.152328359C>A
cDNA c.1267G>T
Protein p.G423*
Source Database RefSeq
Genome Build GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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