FBXW7 G423R - Gene Variant Detail

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Gene FBXW7
Variant G423R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 G423R lies within WD repeat 2 of the Fbxw7 protein (UniProt.org). G423R results in decreased degradation of Cyclin E1 and Cyclin E2 compared to wild-type Fbxw7 in culture (PMID: 35395208), but does not enhance xenograft tumor growth in animal models (PMID: 24838835) and therefore, its effect on Fbxw7 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 G423R

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Transcript NM_033632.3
gDNA chr4:g.152328359C>T
cDNA c.1267G>A
Protein p.G423R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047415902.1 chr4:g.152328275C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532085 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532087.2 chr4:g.152328275C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532087 chr4:g.152328275C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_024454125.1 chr4:g.152328275C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532087.3 chr4:g.152328275C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532086.2 chr4:g.152328275C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532086 chr4:g.152328275C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532086.3 chr4:g.152328275C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
NM_033632 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_017008362 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532084 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532083 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152328359C>T c.1267G>A p.G423R RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References