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Gene | FLT3 |
Variant | D835X |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FLT3 D835X indicates any Flt3 missense mutation that results in the replacement of the aspartic acid (D) at amino acid 835 by a different amino acid. FLT3 codon 835 mutations are hotspot mutations that often result in constitutive phosphorylation of Flt3 and activation of downstream signaling (PMID: 11290608, PMID: 15256420). |
Associated Drug Resistance | |
Category Variants Paths |
FLT3 mutant FLT3 exon20 FLT3 D835X |
Transcript | NM_004119.3 |
gDNA | chr13:g.28018503_28018505 |
cDNA | c.2503_2505 |
Protein | p.D835 |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119 | chr13:g.28018503_28018505 | c.2503_2505 | p.D835 | RefSeq | GRCh38/hg38 |
NM_004119.2 | chr13:g.28018503_28018505 | c.2503_2505 | p.D835 | RefSeq | GRCh38/hg38 |
NM_004119.3 | chr13:g.28018503_28018505 | c.2503_2505 | p.D835 | RefSeq | GRCh38/hg38 |