FLT3 D835X
Gene Variant Detail

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Gene FLT3
Variant D835X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 D835X indicates any Flt3 missense mutation that results in the replacement of the aspartic acid (D) at amino acid 835 by a different amino acid. FLT3 codon 835 mutations are hotspot mutations that often result in constitutive phosphorylation of Flt3 and activation of downstream signaling (PMID: 11290608, PMID: 15256420).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 D835X

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Transcript NM_004119.3
gDNA chr13:g.28018503_28018505
cDNA c.2503_2505
Protein p.D835
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28018503_28018505 c.2503_2505 p.D835 RefSeq GRCh38/hg38
NM_004119 chr13:g.28018503_28018505 c.2503_2505 p.D835 RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018503_28018505 c.2503_2505 p.D835 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FLT3 D835X unknown FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835X
FLT3 exon 14 ins FLT3 D835X NRAS G13D
FLT3 exon 14 ins FLT3 D835X NRAS G12D NRAS G12S
FLT3 exon 14 ins FLT3 F691L FLT3 D835X
FLT3 exon 14 ins FLT3 D835X NRAS G13R
CBL Q367_E373delinsRLK FLT3 exon 14 ins FLT3 D835X NRAS G12D
FLT3 exon 14 ins FLT3 D835X NRAS Q61K
BRAF G469A CBL C404Y FLT3 exon 14 ins FLT3 D835X
FLT3 exon 14 ins FLT3 D835X NRAS Q61R
FLT3 exon 14 ins FLT3 D835X NRAS G13C NRAS G13R
FLT3 exon 14 ins FLT3 D835X NRAS Q61H