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Gene FBXW7
Variant T15_G16insP
Impact List insertion
Protein Effect loss of function
Gene Variant Descriptions FBXW7 T15_G16insP results in the insertion of a proline (P) in the Fbxw7 protein between amino acids 15 and 16 (UniProt.org). T15_G16insP results in decreased binding of Fbxw7 to cyclinE1 and aberrant Fbxw7 localization in cell culture (PMID: 17909001).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 inact mut FBXW7 T15_G16insP

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Transcript NM_033632.3
gDNA chr4:g.152411760_152411761insGAG
cDNA c.45_46insCCT
Protein p.T15_G16insP
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_033632.3 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_011532085 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
NM_001257069.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_011532084 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
NM_033632 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_011532083 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
NM_001257069.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
NM_001257069 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_017008362 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152411760_152411761insGAG c.45_46insCCT p.T15_G16insP RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References