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Gene PIK3CA
Variant E365K
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA E365K lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). E365K results in increased phosphorylation of downstream targets Akt, GSK3-beta, FoxO1, FoxO3a, and S6 in cell culture (PMID: 18829572, PMID: 21266528), and in one of two cell lines, increased cell proliferation and cell viability compared to wild-type Pik3ca in culture (PMID: 29533785), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA E365K

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Transcript NM_006218.4
gDNA chr3:g.179204536G>A
cDNA c.1093G>A
Protein p.E365K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179204536G>A c.1093G>A p.E365K RefSeq GRCh38/hg38
NM_006218 chr3:g.179204536G>A c.1093G>A p.E365K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179204536G>A c.1093G>A p.E365K RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179204536G>A c.1093G>A p.E365K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179204536G>A c.1093G>A p.E365K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179204536G>A c.1093G>A p.E365K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179204536G>A c.1093G>A p.E365K RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179204536G>A c.1093G>A p.E365K RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries