ERBB3 P262H
Gene Variant Detail

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Gene ERBB3
Variant P262H
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ERBB3 (HER3) P262H lies within the extracellular domain of the Erbb3 (Her3) protein (UniProt.org). P262H confers a gain to Erbb3 (Her3) as demonstrated by increased downstream signaling and transformation of Erbb2 (Her2) expressing cells in culture, and tumor growth in a mouse model co-expressing Erbb2 (Her2) (PMID: 23680147)
Associated Drug Resistance
Category Variants Paths

ERBB3 mutant ERBB3 act mut ERBB3 P262H

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Transcript NM_001982.4
gDNA chr12:g.56088073C>A
cDNA c.785C>A
Protein p.P262H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001982 chr12:g.56088073C>A c.785C>A p.P262H RefSeq GRCh38/hg38
NM_001982.3 chr12:g.56088073C>A c.785C>A p.P262H RefSeq GRCh38/hg38
NM_001982.4 chr12:g.56088073C>A c.785C>A p.P262H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ERBB3 P262H gain of function HER inhibitor (Pan) HER2 Inhibitor HER3 Inhibitor Pertuzumab Trastuzumab