ERBB3 P262H
Gene Variant Detail

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Gene ERBB3
Variant P262H
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ERBB3 (HER3) P262H lies within the extracellular domain of the Erbb3 (Her3) protein (UniProt.org). P262H confers a gain to Erbb3 (Her3) as demonstrated by increased downstream signaling and transformation of Erbb2 (Her2) expressing cells in culture, and tumor growth in a mouse model co-expressing Erbb2 (Her2) (PMID: 23680147)
Associated Drug Resistance
Category Variants Paths

ERBB3 mutant ERBB3 act mut ERBB3 P262H

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Transcript NM_001982.4
gDNA chr12:g.56088073C>A
cDNA c.785C>A
Protein p.P262H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001982.4 chr12:g.56088073C>A c.785C>A p.P262H RefSeq GRCh38/hg38
NM_001982 chr12:g.56088073C>A c.785C>A p.P262H RefSeq GRCh38/hg38
NM_001982.3 chr12:g.56088073C>A c.785C>A p.P262H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 P262H Advanced Solid Tumor sensitive Lapatinib Preclinical Actionable In a preclinical study, Tykerb (lapatinib) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor sensitive Duligotuzumab Preclinical Actionable In a preclinical study, MEHD7945A inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor sensitive Trastuzumab Preclinical Actionable In a preclinical study, Herceptin (trastuzumab) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor sensitive Pertuzumab Preclinical Actionable In a preclinical study, Perjeta (pertuzumab) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor resistant Cetuximab Preclinical Actionable In a preclinical study, transformed cell lines expressing ERBB3 (HER3) P262H demonstrated resistance to treatment with Erbitux (cetuximab) (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor sensitive Pictilisib Preclinical Actionable In a preclinical study, the PI3K inhibitor GDC-0941 inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor sensitive Mirdametinib + Pictilisib Preclinical Actionable In a preclinical study, the combination of GDC-0941 and Gomekli (mirdametinib) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H breast cancer sensitive Patritumab deruxtecan Preclinical - Cell culture Actionable In a preclinical study, Patritumab deruxtecan (U3-1402) treatment inhibited growth of a breast cancer cell line expressing ERBB3 (HER3) P262H in culture (PMID: 35503762). 35503762