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Gene FBXW7
Variant R179C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 R179C does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). R179C has been identified in sequencing studies (PMID: 30239046, PMID: 27714650), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 R179C

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Transcript NM_033632.3
gDNA chr4:g.152350091G>A
cDNA c.535C>T
Protein p.R179C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532083 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_011532084 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
NM_033632 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_011532085 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_017008362 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152350091G>A c.535C>T p.R179C RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References