FBXW7 R479P
Gene Variant Detail

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Gene FBXW7
Variant R479P
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FBXW7 R479P lies within the WD repeat domain of the Fbxw7 protein (UniProt.org). R479P results in increased proliferation, migration, invasion, and colony formation in culture (PMID: 31161818), and therefore, is predicted to lead to a loss of Fbxw7 protein function.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 inact mut FBXW7 R479P

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Transcript NM_001349798.2
gDNA chr4:g.152326214C>G
cDNA c.1436G>C
Protein p.R479P
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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