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FBXW7 R689W - Gene Variant Detail

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Gene FBXW7
Variant R689W
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FBXW7 R689W does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). R689W results in increased levels of phosphorylated Rictor, Akt, Gsk, and p70s6 (PMID: 29963728), and decreased interaction with the T244 degron of Myc in the context of an F-box domain deletion in culture (PMID: 35089787), and therefore, is predicted to lead to a loss of Fbxw7 protein function.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 inact mut FBXW7 R689W

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Transcript NM_033632.3
gDNA chr4:g.152322940G>A
cDNA c.2065C>T
Protein p.R689W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047415898.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_017008362 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_011532085 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
NM_033632 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_011532084 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_011532083 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152322940G>A c.2065C>T p.R689W RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries