Gene Variant Detail

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Gene TP53
Variant G245F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 G245F is a hotspot mutation that lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). G245F has been identified in the scientific literature (PMID: 30349649, PMID: 11051249), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 G245F

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Transcript NM_000546.6
gDNA chr17:g.7674229_7674230delGGinsTT
cDNA c.733_734delGGinsTT
Protein p.G245F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.2 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674229_7674230delCCinsAA c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674229_7674230delCCinsAA c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674229_7674230delCCinsAA c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_000546 chr17:g.7674229_7674230delCCinsAA c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674229_7674230delGGinsTT c.733_734delGGinsTT p.G245F RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References