SRC Q531*
Gene Variant Detail

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Gene SRC
Variant Q531*
Impact List nonsense
Protein Effect gain of function
Gene Variant Descriptions SRC Q531* results in a premature truncation of the Src protein at amino acid 531 of 536 (UniProt.org). Q531* confers a gain of function on the Src protein as demonstrated by increased Src kinase activity compared to wild-type Src, transformation of cultured cells, increased cell invasion, and tumor metastasis in animal models (PMID: 9988270).
Associated Drug Resistance
Category Variants Paths

SRC mutant SRC act mut SRC Q531*

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Transcript NM_198291.3
gDNA chr20:g.37403359C>T
cDNA c.1591C>T
Protein p.Q531*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047440412.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
NM_005417.4 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_047440411.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_047440404.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_047440401.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_011529013.2 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
NM_005417.5 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_047440410.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_047440413.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
NM_198291 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
NM_198291.3 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_011529013 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_047440406.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_047440403.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_047440402.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
XM_047440405.1 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
NM_198291.2 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38
NM_005417 chr20:g.37403359C>T c.1591C>T p.Q531* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References