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Gene FBXW7
Variant R689Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 R689Q does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). R689Q is predicted to have activity similar to wild-type Fbxw7 based on comparison and correlation analysis of induced gene expression signatures (PMID: 27147599), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 R689Q

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Transcript NM_033632.3
gDNA chr4:g.152322939C>T
cDNA c.2066G>A
Protein p.R689Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047415900.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_017008362 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_011532085 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_011532083 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
XM_011532084 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38
NM_033632 chr4:g.152322939C>T c.2066G>A p.R689Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FBXW7 R689Q unknown