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Gene KIT
Variant L859S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KIT L859S lies within the protein kinase domain of the Kit protein (UniProt.org). L859S has not been characterized in the scientific literature and therefore, its effect on Kit protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT exon18 KIT L859S

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Transcript NM_000222.3
gDNA chr4:g.54736588_54736589delCTinsAG
cDNA c.2575_2576delCTinsAG
Protein p.L859S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000222 chr4:g.54736588_54736589delCTinsAG c.2575_2576delCTinsAG p.L859S RefSeq GRCh38/hg38
NM_001385288.1 chr4:g.54736597_54736598delCTinsTC c.2575_2576delCTinsTC p.L859S RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54736588_54736589delCTinsAG c.2575_2576delCTinsAG p.L859S RefSeq GRCh38/hg38
NM_001385290.1 chr4:g.54736588_54736589delCTinsAG c.2575_2576delCTinsAG p.L859S RefSeq GRCh38/hg38
XM_005265741.1 chr4:g.54736588_54736589delCTinsAG c.2575_2576delCTinsAG p.L859S RefSeq GRCh38/hg38
XM_005265741 chr4:g.54736588_54736589delCTinsAG c.2575_2576delCTinsAG p.L859S RefSeq GRCh38/hg38
XM_005265742 chr4:g.54736597_54736598delCTinsTC c.2575_2576delCTinsTC p.L859S RefSeq GRCh38/hg38
XM_005265742.3 chr4:g.54736597_54736598delCTinsTC c.2575_2576delCTinsTC p.L859S RefSeq GRCh38/hg38
NM_000222.2 chr4:g.54736588_54736589delCTinsAG c.2575_2576delCTinsAG p.L859S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References