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Gene | TP53 |
Variant | L22P |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 L22P lies within the HRMT1L2 and CCAR2-interacting and transcription activation regions of the Tp53 protein (UniProt.org). L22P has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon2 TP53 L22P |
Transcript | NM_000546.6 |
gDNA | chr17:g.7676530A>G |
cDNA | c.65T>C |
Protein | p.L22P |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000546.5 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001126113 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001126114 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
NM_001126112 | chr17:g.7676530A>G | c.65T>C | p.L22P | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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