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Gene TP53
Variant L22P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 L22P lies within the HRMT1L2 and CCAR2-interacting and transcription activation regions of the Tp53 protein (UniProt.org). L22P has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon2 TP53 L22P

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Transcript NM_000546.6
gDNA chr17:g.7676530A>G
cDNA c.65T>C
Protein p.L22P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.2 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001126114 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001126113 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_001126112 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38
NM_000546 chr17:g.7676530A>G c.65T>C p.L22P RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References