Gene Variant Detail

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Gene APC
Variant S2685G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC S2685G lies within a region of the Apc protein necessary for interaction with DLG1 and MAPRE1 (UniProt.org). S2685G has not been characterized in the scientific literature and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC S2685G

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Transcript NM_000038.6
gDNA chr5:g.112843647A>G
cDNA c.8053A>G
Protein p.S2685G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510 chr5:g.112843647A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112843647A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112843647A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112843647A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001407454.1 chr5:g.112843896A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112843647A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001407456.1 chr5:g.112843896A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001354898.1 chr5:g.112843722A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001407457.1 chr5:g.112843896A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_000038 chr5:g.112843647A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001354898.2 chr5:g.112843722A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001407455.1 chr5:g.112843896A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112843647A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112843647A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112843647A>G c.8053A>G p.S2685G RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References