Gene Variant Detail

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Gene APC
Variant S31fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC S31fs results in a change in the amino acid sequence of the Apc protein beginning at aa 31 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S31fs has not been characterized, however, due to the effects of other truncation mutations downstream of S31 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC S31fs

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Transcript NM_000038.6
gDNA chr5:g.(112754980_112754981)
cDNA c.(91_90)
Protein p.S31fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407448.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407452.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001354896.2 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407460.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001354903.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407449.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001354899.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407458.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407447.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001354896.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407454.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407469.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407456.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001354903.2 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407467.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407457.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407455.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001407459.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38
NM_001354899.2 chr5:g.(112754980_112754981) c.(91_90) p.S31fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
APC S31fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor