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Gene FLT3
Variant A627T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 A627T lies within the protein kinase domain of the Flt3 protein (UniProt.org). A627T has been identified as a drug resistance mutation (PMID: 15374944, PMID: 17620426), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon15 FLT3 A627T

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Transcript NM_004119.3
gDNA chr13:g.28033950C>T
cDNA c.1879G>A
Protein p.A627T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28033950C>T c.1879G>A p.A627T RefSeq GRCh38/hg38
NM_004119 chr13:g.28033950C>T c.1879G>A p.A627T RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28033950C>T c.1879G>A p.A627T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References