ERBB3 T355I
Gene Variant Detail

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Gene ERBB3
Variant T355I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ERBB3 (HER3) T355I lies within the extracellular domain of the Erbb3 (Her3) protein (UniProt.org). T355I confers a gain of function to the Erbb3 (Her3) protein as demonstrated by increased proliferation of ER-positive cells as compared to wild-type ERBB3 (HER3), increased phosphorylation of downstream signaling molecules, and activation of the MAPK pathway in culture (PMID: 29963236).
Associated Drug Resistance
Category Variants Paths

ERBB3 mutant ERBB3 act mut ERBB3 T355I

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Transcript NM_001982.4
gDNA chr12:g.56088823C>T
cDNA c.1064C>T
Protein p.T355I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001982 chr12:g.56088823C>T c.1064C>T p.T355I RefSeq GRCh38/hg38
NM_001982.4 chr12:g.56088823C>T c.1064C>T p.T355I RefSeq GRCh38/hg38
NM_001982.3 chr12:g.56088823C>T c.1064C>T p.T355I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries