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IDH2 R140L - Gene Variant Detail

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Gene IDH2
Variant R140L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions IDH2 R140L lies within the substrate binding region of the Idh2 protein (UniProt.org). R140L has been identified in the scientific literature (PMID: 29448963, PMID: 38980314, PMID: 36064577), but has not been biochemically characterized and therefore, its effect on Idh2 protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

IDH2 mutant IDH2 R140X IDH2 R140L

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Transcript NM_002168.4
gDNA chr15:g.90088702C>A
cDNA c.419G>T
Protein p.R140L
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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