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Gene IDH2
Variant A416fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions IDH2 A416fs results in a change in the amino acid sequence of the Idh2 protein beginning at aa 416 of 452, likely resulting in premature truncation of the functional protein (UniProt.org). A416fs has not been characterized in the scientific literature and therefore, its effect on Idh2 protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

IDH2 mutant IDH2 A416fs

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Transcript NM_002168.4
gDNA chr15:g.(90084841_90084842)
cDNA c.(1246_1245)
Protein p.A416fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168 chr15:g.(90084841_90084842) c.(1246_1245) p.A416fs RefSeq GRCh38/hg38
NM_002168.3 chr15:g.(90084841_90084842) c.(1246_1245) p.A416fs RefSeq GRCh38/hg38
NM_002168.4 chr15:g.(90084841_90084842) c.(1246_1245) p.A416fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References