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Gene IDH2
Variant G145fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions IDH2 G145fs results in a change in the amino acid sequence of the Idh2 protein beginning at aa 145 of 452, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of sites critical for catalysis (UniProt.org), G145fs is predicted to lead to a loss of Idh2 protein function.
Associated Drug Resistance
Category Variants Paths

IDH2 mutant IDH2 inact mut IDH2 G145fs

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Transcript NM_002168.4
gDNA chr15:g.(90088688_90088689)
cDNA c.(433_432)
Protein p.G145fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168.3 chr15:g.(90088688_90088689) c.(433_432) p.G145fs RefSeq GRCh38/hg38
NM_002168.4 chr15:g.(90088688_90088689) c.(433_432) p.G145fs RefSeq GRCh38/hg38
NM_002168 chr15:g.(90088688_90088689) c.(433_432) p.G145fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
IDH2 G145fs loss of function - predicted