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Gene IDH2
Variant E208*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions IDH2 E208* results in a premature truncation of the Idh2 protein at amino acid 208 of 452 (UniProt.org). Due to the loss of sites critical for catalysis (UniProt.org), E208* is predicted to lead to a loss of Idh2 protein function.
Associated Drug Resistance
Category Variants Paths

IDH2 mutant IDH2 inact mut IDH2 E208*

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Transcript NM_002168.4
gDNA chr15:g.90088415C>A
cDNA c.622G>T
Protein p.E208*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168.3 chr15:g.90088415C>A c.622G>T p.E208* RefSeq GRCh38/hg38
NM_002168 chr15:g.90088415C>A c.622G>T p.E208* RefSeq GRCh38/hg38
NM_002168.4 chr15:g.90088415C>A c.622G>T p.E208* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
IDH2 E208* loss of function - predicted