IDH2 I441T
Gene Variant Detail

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Gene IDH2
Variant I441T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions IDH2 I441T does not lie within any known functional domains of the Idh2 protein (UniProt.org). I441T has been identified in sequencing studies (PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Idh2 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

IDH2 mutant IDH2 I441T

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Transcript NM_002168.4
gDNA chr15:g.90084303A>G
cDNA c.1322T>C
Protein p.I441T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168 chr15:g.90084303A>G c.1322T>C p.I441T RefSeq GRCh38/hg38
NM_002168.3 chr15:g.90084303A>G c.1322T>C p.I441T RefSeq GRCh38/hg38
NM_002168.4 chr15:g.90084303A>G c.1322T>C p.I441T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References