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Gene PIK3CA
Variant E542K
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA E542K is a hotspot mutation that lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E542K results in increased phosphorylation of Akt, growth factor-independent cell survival, and is transforming in cell culture (PMID: 16533766, PMID: 26627007, PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA E542K

PIK3CA mutant PIK3CA exon10 PIK3CA E542X PIK3CA E542K

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Transcript NM_006218.4
gDNA chr3:g.179218294G>A
cDNA c.1624G>A
Protein p.E542K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
NM_006218 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218294G>A c.1624G>A p.E542K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA E542K gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor
PIK3CA E542K PTEN loss
PIK3CA E542K PIK3CA amp
CDKN2A loss PIK3CA E542K PTEN loss
CDKN2A loss PIK3CA E542K PIK3CA amp
HRAS mut PIK3CA E542K
PIK3CA E542K PIK3CA F744L
PIK3CA E542K TSC1 LOH
PIK3CA E542K PIK3CA E674Q
PIK3CA E542K PIK3CA H1065L
BRAF V600E PIK3CA E542K
BRAF V600E PIK3CA W11C PIK3CA E542K
CDKN2A S12* PIK3CA E542K