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Gene IDH2
Variant W244*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions IDH2 W244* results in a premature truncation of the Idh2 protein at amino acid 244 of 452 (UniProt.org). Due to the loss of a site critical for catalysis (UniProt.org), W244* is predicted to lead to a loss of Idh2 protein function.
Associated Drug Resistance
Category Variants Paths

IDH2 mutant IDH2 inact mut IDH2 W244*

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Transcript NM_002168.4
gDNA chr15:g.90087523C>T
cDNA c.731G>A
Protein p.W244*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168 chr15:g.90087523C>T c.731G>A p.W244* RefSeq GRCh38/hg38
NM_002168.4 chr15:g.90087523C>T c.731G>A p.W244* RefSeq GRCh38/hg38
NM_002168.3 chr15:g.90087523C>T c.731G>A p.W244* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References