FLT3 G831E - Gene Variant Detail

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Gene FLT3
Variant G831E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 G831E lies within the protein kinase domain of the Flt3 protein (UniProt.org). G831E demonstrates autophosphorylation and activation of downstream signaling at similar levels to wild-type Flt3 in culture, but is also predicted to stabilize the autoinhibitory conformation of the Flt3 protein and lead to a loss of function based on structural modeling (PMID: 18068628), and therefore, its effect on Flt3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 G831E

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Transcript NM_004119.3
gDNA chr13:g.28018516C>T
cDNA c.2492G>A
Protein p.G831E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018516C>T c.2492G>A p.G831E RefSeq GRCh38/hg38
NM_004119 chr13:g.28018516C>T c.2492G>A p.G831E RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018516C>T c.2492G>A p.G831E RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References