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Gene FLT3
Variant I836del
Impact List deletion
Protein Effect gain of function
Gene Variant Descriptions FLT3 I836del results in the deletion of an amino acid in the protein kinase domain activation loop of the Flt3 protein at amino acid 836 (PMID: 12663439). I836del results in constitutive phosphorylation of Flt3 and activation of Stat5, Erk signaling, leading to transformation of cultured cells (PMID: 15256420).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 I836del

FLT3 mutant FLT3 exon20 FLT3 I836del

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Transcript NM_004119.3
gDNA chr13:g.28018500_28018502delGAT
cDNA c.2508_2510delCAT
Protein p.I836delI
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28018500_28018502delGAT c.2508_2510delCAT p.I836delI RefSeq GRCh38/hg38
XM_011535015.3 chr13:g.28015679_28015681delATC c.2506_2508delATG p.M836delM RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018500_28018502delGAT c.2508_2510delCAT p.I836delI RefSeq GRCh38/hg38
NM_004119 chr13:g.28018500_28018502delGAT c.2508_2510delCAT p.I836delI RefSeq GRCh38/hg38
XM_017020486.1 chr13:g.28015186_28015188delCAT c.2506_2508delATG p.M836delM RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28015679_28015681delATC c.2506_2508delATG p.M836delM RefSeq GRCh38/hg38
XM_017020486.2 chr13:g.28015186_28015188delCAT c.2506_2508delATG p.M836delM RefSeq GRCh38/hg38
XM_017020486 chr13:g.28015186_28015188delCAT c.2506_2508delATG p.M836delM RefSeq GRCh38/hg38
XM_011535015 chr13:g.28015679_28015681delATC c.2506_2508delATG p.M836delM RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FLT3 I836del gain of function FLT3 Inhibitor
FLT3 exon 14 ins FLT3 I836del