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FLT3 Y572C - Gene Variant Detail

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Gene FLT3
Variant Y572C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 Y572C lies within the cytoplasmic domain of the Flt3 protein (UniProt.org). Y572C results in constitutive phosphorylation of Flt3, activation of Erk, Akt and Stat signaling, and is transforming in cell culture (PMID: 18068628, PMID: 30651561).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 Y572C

FLT3 mutant FLT3 exon14 FLT3 Y572C

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Transcript NM_004119.3
gDNA chr13:g.28034204T>C
cDNA c.1715A>G
Protein p.Y572C
Source Database RefSeq
Genome Build GRCh38/hg38

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