FLT3 V592A
Gene Variant Detail

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Gene FLT3
Variant V592A
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 V592A lies within a region important for maintaining kinase activity in the Flt3 protein (UniProt.org). V592A results in constitutive phosphorylation of Flt3, activation of Stat5 signaling, upregulation of Bcl-x(L), and is transforming in cell culture (PMID: 16410449).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 V592A

FLT3 mutant FLT3 exon14 FLT3 V592A

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Transcript NM_004119.3
gDNA chr13:g.28034144A>G
cDNA c.1775T>C
Protein p.V592A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28034144A>G c.1775T>C p.V592A RefSeq GRCh38/hg38
NM_004119 chr13:g.28034144A>G c.1775T>C p.V592A RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28034144A>G c.1775T>C p.V592A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 V592A hematologic cancer sensitive Gilteritinib Preclinical - Cell culture Actionable In a preclinical study, Xospata (gilteritinib) treatment decreased viability in a cell line expressing FLT3 V592A in culture (PMID: 40196870). 40196870
FLT3 V592A hematologic cancer sensitive Quizartinib Preclinical - Cell culture Actionable In a preclinical study, Vanflyta (quizartinib) treatment decreased viability in a cell line expressing FLT3 V592A in culture (PMID: 40196870). 40196870
FLT3 V592A hematologic cancer sensitive Midostaurin Preclinical - Cell culture Actionable In a preclinical study, Rydapt (midostaurin) treatment decreased viability in a cell line expressing FLT3 V592A in culture (PMID: 40196870). 40196870