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Gene FLT3
Variant S985fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions FLT3 S985fs results in a change in the amino acid sequence of the Flt3 protein beginning at aa 985 of 993, likely resulting in premature truncation of the functional protein (UniProt.org). S985fs has been identified in sequencing studies (PMID: 25562415), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 S985fs

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Transcript NM_004119.3
gDNA chr13:g.(28004081_28004082)
cDNA c.(2953_2952)
Protein p.S985fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.(28004081_28004082) c.(2953_2952) p.S985fs RefSeq GRCh38/hg38
NM_004119 chr13:g.(28004081_28004082) c.(2953_2952) p.S985fs RefSeq GRCh38/hg38
NM_004119.2 chr13:g.(28004081_28004082) c.(2953_2952) p.S985fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References