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Gene CHEK2
Variant D134Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CHEK2 D134Y lies within the FHA domain of the Chek2 protein (UniProt.org). D134Y has not been characterized in the scientific literature and therefore, its effect on Chek2 protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

CHEK2 mutant CHEK2 D134Y

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Transcript NM_007194.4
gDNA chr22:g.28725287C>A
cDNA c.400G>T
Protein p.D134Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_145862 chr22:g.28725287C>A c.400G>T p.D134Y RefSeq GRCh38/hg38
NM_145862.2 chr22:g.28725287C>A c.400G>T p.D134Y RefSeq GRCh38/hg38
XM_011529843 chr22:g.28725287C>A c.400G>T p.D134Y RefSeq GRCh38/hg38
NM_001349956.1 chr22:g.28725287C>A c.400G>T p.D134Y RefSeq GRCh38/hg38
NM_145862.2 chr22:g.28725287C>A c.400G>T p.D134Y RefSeq GRCh38/hg38
NM_001349956.2 chr22:g.28725287C>A c.400G>T p.D134Y RefSeq GRCh38/hg38
NM_007194.3 chr22:g.28725287C>A c.400G>T p.D134Y RefSeq GRCh38/hg38
NM_007194 chr22:g.28725287C>A c.400G>T p.D134Y RefSeq GRCh38/hg38
NM_007194.4 chr22:g.28725287C>A c.400G>T p.D134Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References