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Gene CHEK2
Variant L338R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CHEK2 L338R lies within the protein kinase domain of the Chek2 protein (UniProt.org). L338R has not been characterized and therefore, its effect on Chek2 protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

CHEK2 mutant CHEK2 L338R

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Transcript NM_007194.4
gDNA chr22:g.28696983A>C
cDNA c.1013T>G
Protein p.L338R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_007194.4 chr22:g.28696983A>C c.1013T>G p.L338R RefSeq GRCh38/hg38
NM_007194 chr22:g.28696983A>C c.1013T>G p.L338R RefSeq GRCh38/hg38
NM_007194.3 chr22:g.28696983A>C c.1013T>G p.L338R RefSeq GRCh38/hg38
XM_006724114.4 chr22:g.28689184A>C c.1013T>G p.L338R RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References