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Gene CHEK2
Variant L355P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CHEK2 L355P lies within the protein kinase domain of the Chek2 protein (UniProt.org). L355P has been identified in sequencing studies (PMID: 18186519, PMID: 17145815), but has not been biochemically characterized and therefore, its effect on Chek2 protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

CHEK2 mutant CHEK2 L355P

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Transcript NM_007194.4
gDNA chr22:g.28696932A>G
cDNA c.1064T>C
Protein p.L355P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_145862.2 chr22:g.28695818_28695819delTTinsCC c.1063_1064delTTinsCC p.L355P RefSeq GRCh38/hg38
NM_007194.4 chr22:g.28696932A>G c.1064T>C p.L355P RefSeq GRCh38/hg38
NM_007194 chr22:g.28696932A>G c.1064T>C p.L355P RefSeq GRCh38/hg38
NM_145862 chr22:g.28695818_28695819delAAinsGG c.1063_1064delTTinsCC p.L355P RefSeq GRCh38/hg38
NM_145862.2 chr22:g.28695818_28695819delTTinsCC c.1063_1064delTTinsCC p.L355P RefSeq GRCh38/hg38
NM_007194.3 chr22:g.28696932A>G c.1064T>C p.L355P RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries