FLT3 F691L
Gene Variant Detail

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Gene FLT3
Variant F691L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FLT3 F691L lies within the protein kinase domain of the Flt3 protein (PMID: 23430109). F691L has been demonstrated to promote secondary drug resistance in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 23430109, PMID: 19318574, PMID: 22504184, PMID: 29187377), but is not transforming in cell culture (PMID: 30651561), and therefore, is predicted to have no effect on Flt3 protein function.
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon17 FLT3 F691L

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Transcript NM_004119.3
gDNA chr13:g.28027224A>G
cDNA c.2071T>C
Protein p.F691L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28027224A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28027224A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
NM_004119 chr13:g.28027224A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
XM_011535015 chr13:g.28027167A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28027167A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
XM_011535015.3 chr13:g.28027167A>G c.2071T>C p.F691L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 F691L hematologic cancer sensitive Narazaciclib Preclinical - Cell culture Actionable In a preclinical study, Narazaciclib (ON123300) inhibited proliferation of cells expressing FLT3 F691L in culture (PMID: 38641704). 38641704